Indigo naturalis on skin care

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Indigo naturalis on skin care

Indigo naturalis, well known as Qing Dai in traditional Chinese medicine, extracted from the leaf / stem with leaf of Baphicacanthus cusia (Nees) Bremek, Polygonum tinctorium Ait and Isatis indigotica Fort, of family Acanthaceae. The common use of indigo naturalis for ancient Chinese is to dye cloth and painting. But it is used in various treatments such as skin disorder, snake bite, even acute promyelocytic leukemia in TCM.

Indigo naturalis effects on skin disorder

 

Modern science find its more applications on treating skin diseases like psoriasis / eczema.

 

To investigate the anti-proliferating effects of indigo naturalis and indirubin on epidermal keratinocytes, the researchers made some experiments about indigo naturalis and found that  CDC25B also plays an important role in the hyper-proliferation of epidermal keratinocytes which can be suppressed by anti-psoriatic drug indigo naturalis and its component, indirubin, except being a common therapeutic target in various cancers.

 

Indigo naturalis and indirubin were confirmed to down-regulate CDC25B Gene expression significantly at both the mRNA and protein levels. The growth-dependent expression of CDC25B was demonstrated by the increased expression in serum-stimulated and immortalized keratinocytes. The activation of EGF receptor, known to be highly expressed in psoriatic lesions, was inhibited by indigo naturalis or indirubin. The cell proliferation and CDC25B expression of epidermal keratinocytes were induced by EGF alone and confirmed to be inhibited by indigo naturalis or indirubin.

 

The researchs also indicate that the anti-psoriatic effects of indigo naturalis are mediated, at least in part, by modulating the proliferation and differentiation of keratinocytes, with indirubin as the major active component.

 

 

Indigo naturalis effects on Pediatric Psoriasis

To treat pediatric psoriasis is intractable, as it may be linked to potential adverse effects on children. Traditional Chinese medicine comes through over 1000 years and provides various effective treatments for inflammatory skin diseases, among which indigo naturalis is one of the chosen medicine.  The clinical trials approves that topical treatment with indigo naturalis composite ointments effects on pediatric psoriasis without adverse actions. indigo naturalis is safe and effective.

 

Through clinical trials, it is easily found that topical application of indigo naturalis ointment is a novel, safe and effective therapy for psoriasis, at least in part, by modulating the proliferation and differentiation of keratinocytes in epidermis, as well as by inhibiting the infiltration of T lymphocytes and therefore the subsequent inflammatory reactions in psoriatic lesions.

To get more indigo naturalis benefits, people can make more preparation like indigo naturalis cream / indigo naturalis ointment, and some handmade products like indigo naturalis soaps. Of course, you can also make indigo naturalis as a safe eye pencil and lip stick for safe  consideration.

 

 

Reference

1. http://archderm.jamanetwork.com/article.aspx?articleid=1105529

2. http://www.ncbi.nlm.nih.gov/pubmed/22721997

3. http://www.jdsjournal.com/article/S0923-1811(09)00059-0/abstract

4. http://www.ncbi.nlm.nih.gov/pubmed/17014654

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